09 Jan 2014/
Primary brain tumors, originate within the brain. According to the World Health Organization (WHO), the incidence rate for glioblastoma is approximately 3-4/100,000 person-years but varies in different world regions. Rates generally tend to be higher in developed, industrial countries. The most common primary malignant brain tumor is glioblastoma multiforme (GBM). GBM tumors are mostly sporadic (formed randomly), without any known genetic predisposition. Treatment can include surgery, radiation, and chemotherapy. However, treatment is rarely effective and virtually all patients with GBM die of the disease within two years of initial diagnosis. Although there has been progress in the treatment of GBM as a result of a new treatment regimen that combines maximum surgical resection with radiotherapy and concurrent and temozolomide chemotherapy, two-year and five-year survival rates are only 25% and 10%, respectively.